秒速快三投注平台

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  2020年5月4日,国际学术期刊 Nature Metabolism 在线发表了中国科秒速快三投注平台上海营养与健康研究所丁秋蓉课题组的研究论文“MRG15 orchestrates rhythmic epigenomic remodeling and controls hepatic lipid metabolism”。该研究发现MRG15作为一个进化上保守的表观调控因子在调控肝脏组织染色质开放状态和脂代谢基因转录活性的节律性振荡中行使重要的分子开关作用。研究提示MRG15复合物在肝脏组织感应外界营养状态,并在营养丰富环境下进行有效能量储存的过程中起重要作用。该研究为营养过剩环境下脂质代谢紊乱导致的代谢性疾病提供了新的分子靶标。

  diqiuzizhuanchanshenglezhouyejiaoti,zaizhangqidejinhuaguochengzhong,shengwutichanshengleshengwuzhongjielvxitong,shidexingweiheshenglijinchengtongbuyuguangxiandezhouqibianhua,yishinengliangdechucunheliyongdadaozuiyouzhuangtai。qianqiyanjiufaxianquanjiyinzufanweineideransezhikaifanghebihe,rnajuhemeiiidejiyinzujiehehexinshengzhuanluhuoxingchengxianmingxiandezhouyejielv。yiganzangweili,jiyinbiaodapufenxifaxian5-20%dejiyinzaiganzangzuzhizhongcunzai24hdezhendangbiaoda,qieqizhongdaduoshujiyinduidaixieyouzhongyaodiaokongzuoyong,shuomingransezhizhongsucengmiandezhouyejielvdiaokongzaiwaizhoudaixiezuzhizhong(ruganzang)duidaixiejiyindezhengtizhuanludiaokong,jiernengliangdechucunhexiaohaopinghengfeichangzhongyao。erwaizhoudaixiezuzhiruheganyingwaijieyingyangzhuangtaidejielvxingbianhua,bingzairansezhizhongsucengmianzuochujishixiangyingshidaixielingyuyoudaihuidadejibenwenti。

  mrg15shiyigejinhuashangfeichangbaoshoudebiaoguandiaokongyinzi,qianqibeifaxiancanyudiaokongxibaozengzhi、dnaxiufuhegetifayuguocheng。suiranmrg15jiyinfujindejiyinzuquyuzairenleiyichuanxuezhongbeijiandingweixinxueguanjibingyiganquyu,danshangquefazhenduimrg15zaidaixiezhongdegongnengyanjiu。yanjiurenyuanzaixitongjiancemrg15jiyinzujieheweidianshifaxian,zaiganzangzuzhizhongmrg15jiehezaiduogezhongyaozhidaixiejiyinqidongzihezengqiangziquyu,bingtongshifaxianyigeyouqudexianxiang: mrg15dejiyinzujiehechengxianmingxiandejielvxing——zaixiaoshuyejianjinshizhuangtaixia,mrg15jiehedejiyinzuweidianchaoguo1wange;erzaibaitianfeijinshizhuangtaixia,mrg15dejiyinzujieheweidianzhiyou57ge;ergaibianjinshishijiannengmingxiangaibianmrg15jiyinzujiehedejielvxing。jinyibudeyanjiufaxian,mrg15yujiyinzudejielvxingjiehekecujinransezhikaifang,zengqiangrnajuhemeiiidejiyinzujiehe,tigaojiyinzhuanluhuoxing;erzaimrg15qiaochudeganzangzuzhizhong,quanjiyinzufanweineipol iijiyinzujiehedejielvxingbeimingxianpohuai,duogezhidaixiejiyinbiaodaxianzhujiangdi,tishimrg15zaijielvxingransezhizhongsuhezhidaixiejiyinbiaodadiaokongzhongqiguanjianzuoyong。

  yanjiurenyuanjinyibuzhenduidaozhimrg15jielvxingjiyinzujieheshangyoujizhijinxingleyanjiu,chubufaxianganzangheshoutilrh-1(youmingnr5a2)bufenjiedaolemrg15zaizhidaixiejiyinzhuanludiaokongquyudejiehe。lrh-1yumrg15cunzaidanbaixianghuzuoyong,shiyanjieguoxianshilrh-1dedanbaibiaodaliangyijilrh-1yumrg15dedanbaixianghuzuoyongmingxianshoujielvheshangyouyingyangxinhaodiaokong,tishileyizhongjingyoulrh-1diaokongmrg15jiyinzujiehedeshangyouyingyangganyingjizhi。

  dangtongguocrisprjishuzaichengtixiaoshuganzangzuzhiliqiaochumrg15jineryizhizheiyiguochenghou,xiaoshunengmingxiandikanggaozhiyinshidaozhideganzangzhifangjilei,gaishandaixiepingheng。gengyouyisideshi,fdapizhundeyaowuajiaquban(argatroban)beifaxiankeyigaoqinhelijiehemrg15,yizhimrg15degongneng,congeryouxiaoyizhiganzangzhidijilei,tishimrg15shiyigechengyaoxingjiaoqiangdefenzibadian。zongshang,cixiangyanjiujieshileganzangxibaoganyingshangyouyingyangxinhao,bingzairansezhizhongsushuipingzuochujishixiangyingdeyizhongchuandaojizhiheqijianguanjianxianjieyinzimrg15。

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  yuanwenlianjie:


图1. MRG15是调控肝脏节律性染色质重塑和脂代谢基因表达的表观分子开关。

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